Pabitra Sahoo
Biography
Axona protein protein synthesis, mRNA transport, Stress granules, localized protein synthesis and its role in neural repair, and neurodevelopment.
Education
B.S., Utkal University, India, 2005.
M.S., University of Hyderabad, India, 2007
Ph.D., National Centre for Cell Science, University of Pune, 2013.
Postdoctoral fellow, Twiss Lab, University of South Carolina, 2023.
Expertise
Cell Biology, Molecular Biology, Biochemistry, Molecular & Cellular Neuroscience, Localized Protein Synthesis, Neural Repair, Neuronal Development, Post-transcriptional Gene Regulation, Spatial Transcriptomics
Publications
For full list of publications please see: http://scholar.google.com/citations?hl=en&user=5u_zAyoAAAAJ
Selected Publications
1. P.K. Sahoo, S.J. Lee, P. Jaiswal, S. Alber, A.N. Kar, S.M. Randolph, T. Smith, B. Singh, T.S. Yu-Ho, A. Urisman, A. Burlingame, C. Woolf, M. Fainzilber, A.W. English, J.L. Twiss. Inhibiting G3BP1 increases axonal mRNA translation and accelerates nerve regeneration (2018). Nature Communications 9(1):3358.
2. P.K. Sahoo, D. Smith, J.L. Twiss. Axonal mRNA transport and translation at a glance (2018). J Cell Science 131(8):1-8.
3. M. Terenzio, S. Koley, N. Samra, I. Rishal, Q. Zhao, P.K. Sahoo, A. Urisman, L. Marvaldi, J.A. Oses-Prieto, C. Forester, C. Gomes, A. Kalinski, A. Di Pizio, E. Doron-Mandel, R.B. Perry, I. Koppel, J.L. Twiss, A.L. Burlingame, M. Fainzilber (2018). Locally Translated mTOR Controls Axonal Local Translation in Nerve Injury. Science 359(6382):1416-1421.
4. T. Smith*, P.K. Sahoo*, A.N. Kar, J.L. Twiss. Intra-axonal mechanisms driving axon regeneration (2020). Brain Research, CMT volume 1740: 146864. * co-first authors.
5. P.K. Sahoo, A.N. Kar, S.J. Lee, S.M. Randolph, M. Terenzio, N. Samra, P. Patel, E. Thames, B. Jones, M. Fainzilber, J.L. Twiss. A Ca2+-dependent switch activates axonal Casein Kinase 2α translation and drives G3BP1 granule disassembly for axon regeneration (2020). Current Biology 30: 1-14.
6. I. Dalla Costa*, C.N. Buchanan*, M. Zdradzinski*, P.K. Sahoo, T.P. Smith, E. Thames, A.N. Kar, J.L. Twiss. The functional organization of axonal mRNA transport and translation (2021). Nature Reviews Neuroscience 22: 77-91. * co-first authors.
7. P. Patel*, C. Buchanan*, M.D. Zdradzinski, P.K Sahoo, A.N. Kar, S.J. Lee, L. Vaughn, A. Urisman, J.A. Oses-Prieto, M.D. Orco, D.E. Cassiday, I. Dalla Costa, S. Miller, E. Thames, T.P. Smith, A.L. Burlingame, N. Perrone-Bizzozero, J.L. Twiss. Intra-axonal translation of Khsrp mRNA slows axon regeneration by destabilizing localized mRNAs (2022). Nucleic Acid Research 50(10): 5772–5792,. * co-first authors.
8. P.K. Sahoo†, J.L. Twiss. Profiling locally translated mRNAs in regenerating axons (2023). Methods in Molecular Biology, Axon Regeneration: 145-161. † Corresponding author.
9. S. Alber, P. Di-Matteo, M.D. Zdradzinski, L. Marvaldi, R. Kawaguchi, K.F. Medzihradszky, E. Doron-Mandel, N. Okladinikov, I. Rishal, R. Nevo, P.K. Sahoo, A.L. Burlingame, G. Coppola, J.L. Twiss, and M. Fainzilber. PTBP1 Regulates Injury Responses and Sensory Pathways in Adult Peripheral Neurons (2023). Science Advances 9(30):eadi0286.
Patents
2. A.N. Kar, P.K. Sahoo, J.L. Twiss, S. McGill, E. Perlson, T. Altman, A. Razvan, I.Tal Gradus-Pery, A. Dori (2022). Targeting G3BP Aggregation To Prevent Neurodegeneration. Application No. 16881096; Pending.
1. J.L. Twiss, P.K. Sahoo. (2017). Targeting G3BP Proteins To Accelerate Nerve Regeneration. USA Patent No. US 10668128 B2; Issued 06/02/2020.